Obesity surgery and satiety control

Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity

CONTEXT Roux-en-Y gastric bypass (RYGB) surgery is an effective long-term intervention for weight loss maintenance, reducing appetite, and also food reward, via unclear mechanisms. OBJECTIVE To investigate the role of elevated satiety gut hormones after RYGB, we examined food hedonic-reward responses after their acute post-prandial suppression. DESIGN These were randomized, placebo-controll...

Satiety mechanisms in genetic risk of obesity.

IMPORTANCE A better understanding of the cause of obesity is a clinical priority. Obesity is highly heritable, and specific genes are being identified. Discovering the mechanisms through which obesity-related genes influence weight would help pinpoint novel targets for intervention. One potential mechanism is satiety responsiveness. Lack of satiety characterizes many monogenic obesity disorders...

Leptin: The Satiety Hormone and its Influence on Obesity

The Ob gene, which is known to encode the 16 kDa protein hormone leptin, is one of the main genes that has been linked to the obesity phenotype in humans. Examination of Ob gene expression, as well as leptin’s mode of action in the hypothalamus through an intracellular signaling cascade, reveals the complexities of weight regulation (Friedman & Halaas, 1998). Single point mutations in the Ob ge...

Neural Control of Hunger, Appetite, and Satiety **

Hunger, appetite, and satiety are often regarded as problems in the physiology of digestion. In recent years, however, they have been studied more and more commonly as functions of the brain. This latter point of view, i.e., neurophysiology, is used in the paper which follows, and the regulation of food intake is here described in terms of mechanisms and reactions that characterize the nervous ...

Is satiety (lack thereof) the culprit with obesity?